It’s important to seek professional help if you or someone you know is experiencing symptoms of depression. Early intervention can help improve outcomes and lead to a better quality of life.

What Is Depression?

Depression is a mental health disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest or pleasure in activities that a person used to enjoy. It can also cause physical symptoms such as changes in appetite or sleep patterns, fatigue, and difficulty concentrating. Depression can range from mild to severe and can be caused by a combination of genetic, environmental, and psychological factors. Treatment for depression often involves a combination of therapy, medication, lifestyle changes, and support from loved ones and professionals.


Signs & Symptoms Of Depression

The signs and symptoms of depression can vary from person to person, but commonly include:

  • Persistent feelings of sadness, hopelessness, or emptiness
  • Loss of interest or pleasure in activities once enjoyed
  • Changes in appetite, including overeating or loss of appetite
  • Changes in sleep patterns, including insomnia or sleeping too much
  • Fatigue or lack of energy
  • Difficulty concentrating or making decisions
  • Feelings of worthlessness or excessive guilt
  • Recurrent thoughts of death or suicide
  • Restlessness or irritability
  • Physical symptoms such as headaches or body aches

It’s important to note that not everyone with depression will experience all of these symptoms, and the severity of symptoms can vary. Treatment for depression can be highly effective and can involve therapy, medication, lifestyle changes, and support from loved ones and professionals.

Ketamine: A Paradigm Shift for Depression Research and Treatment

Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy. 1


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Stages of Depression

There are no specific stages of depression, as the disorder can present itself differently in each individual. However, depression is often characterised by different levels of severity, ranging from mild to severe. It’s important to note that depression is a complex disorder that can affect each person differently, and the severity of symptoms can fluctuate over time.


This may involve feeling sad or blue, loss of interest in activities, changes in sleep patterns, and changes in appetite.



Usually moderate depression involves more intense feelings of sadness or hopelessness, decreased energy levels, trouble concentrating, and difficulty completing daily tasks.



Severe depression can cause extreme feelings of despair, loss of interest in all activities, thoughts of suicide, and physical symptoms such as chronic pain or digestive problems.

The Integration of MDMA and Ketamine in Psychotherapy: An Exploration of Their Complementary Benefits

While traditional talk therapy can be effective for many people, there is growing interest in exploring alternative forms of therapy that involve the use of mind-altering substances. Two such substances that are currently being explored for their therapeutic potential are MDMA and Ketamine. Read more

The Science Behind Ketamine and Its Use in Psychotherapy

Discover the science behind ketamine and its use in psychotherapy. Explore how this emerging field is changing mental health treatment Read more